Lit Review

Roundup: 3 Interesting CTC articles published in the last 30 Days

The circulating tumor cell literature is expanding rapidly, with over 30 publications in the last month alone! So I have decided to do a roundup of articles I found interesting and impactful about once per month. If there are other papers you found interesting, I encourage you to share them. Clinical applications of CTC analysis Ivanov et al. Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples.

CTC genetic heterogeneity, a window into the metastatic process

x-posted to Kirby Lab Student Blog Keywords BCa: Breast Cancer CTC: Circulating tumor cell. Read about what they are and why they’re important here. Epithelial cell surface marker: A protein or receptor sticking out of the cell membrane of epithelial cells. EMT: Epithelial-to-mesenchymal transition, where cells lose biomarkers associated with their organ of origin and become more stem cell-like. SNR: Signal-to-noise ratio. Tumor genetic heterogeneity has emerged as an effective biomarker of malignant processes1-4.