The circulating tumor cell literature is expanding rapidly, with over 30 publications in the last month alone! So I have decided to do a roundup of articles I found interesting and impactful about once per month. If there are other papers you found interesting, I encourage you to share them.
Clinical applications of CTC analysis Ivanov et al. Chip-Based Nanostructured Sensors Enable Accurate Identification and Classification of Circulating Tumor Cells in Prostate Cancer Patient Blood Samples.
x-posted to Kirby Lab Student Blog
Keywords BCa: Breast Cancer CTC: Circulating tumor cell. Read about what they are and why they’re important here. Epithelial cell surface marker: A protein or receptor sticking out of the cell membrane of epithelial cells. EMT: Epithelial-to-mesenchymal transition, where cells lose biomarkers associated with their organ of origin and become more stem cell-like. SNR: Signal-to-noise ratio. Tumor genetic heterogeneity has emerged as an effective biomarker of malignant processes1-4.
Keywords CTC: Circulating tumor cell. Read about what they are and why they’re important here. Leukocyte: White blood cell. Erythrocyte: Red blood cell. I’ve previously discussed how to sort CTCs, and the standards used to characterize device performance. Today, I’ll explain what some of the most common evaluation metrics are, and place them in context of eventual clinical/industrial application.
What are common performance criteria? Capture Efficiency is number of target cells captured divided by total number of target cells introduced into the cell isolation system.
x-posted at Kirby Lab Student Blog
Keywords Cell Surface Marker: Some protein or receptor sticking out of the cell membrane. I explain this more in depth in my immunocapture post. CTC: Circulating tumor cell. Read about what they are and why they’re important here. Microemboli: A small mass of cells or tissue inside the bloodstream. Platelets: aka thrombocytes, important in the formation of blood clots. Phenotype: Observable characteristics of a cell.