Roundup: Circulating Tumor Cell Tech Review Papers

Keywords

Biomarker:  A detectable cell characteristic that tells us something about its biological state. CTC: Circulating tumor cell. Read about what they are and why they’re important here. I have been out of town most of this week at the World CTC Conference in Boston, which was a great forum to hear about the latest in CTC research, and I had a very engaged audience at my presentation. However, I didn’t have time to write up my next post in my series on sorting techniques. In the meantime, here is a roundup of previews paper I think are really great overviews CTC tech and the field in general.

Clinically-Oriented CTC applications reviews

Parkinson et al. Considerations in the development of circulating tumor cell technology for clinical use. J Transl. Med. 2012; 10:138 (Open Access on Pubmed) Focused on developing CTCs as an assay and biomarker development tool, with clear criteria on what is needed to demonstrate utility. Pantel et al. Circulating tumour cells in cancer patients: challenges and perspectives. Trends Mol. Med. 2010; 16(9):398-406 (Abstract available on Pubmed ) Outlines commercially available CTC isolation technologies at the time of publication with specific interest in using CTCs as a surrogate for bone marrow tumor cells, but generally applicable to the field.

Engineering-Oriented CTC technology development reviews

Pratt and Huang et al. Rare cell capture in microfluidic devices. Chem. Eng. Sci. 2011; 66(7):1508-1522 (Available on Kirby Lab webpage) A review I wrote two years ago focused purely on academic rare cell capture tech development. Contains systematic comparisons and evaluations of device performance metrics across a variety of isolation techniques. Chen et al. Microfluidic approaches for cancer cell detection, characterization, and separation. Lab on Chip 2012; 12:1753-1767 (Abstract available on LOC website) Outlines newest academic cancer cell isolation technology. Discuses strengths and limitations of each technology, and nicely-organized tables of the literature. If you are interested purely in the fluid physics involved in rare cell capture devices, my labmate Jim Smith also wrote a review focused on that topic (available here).

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Erica D. Pratt
Postdoctoral Associate

My research interests include microfluidics and blood-based tumor analyte detection strategies.

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